Professor

Sung-Kee Chung
Professor(full)

    Tel:  054-279-2103 (in Korea)
          +82-54-279-2103 (abroad)
    Fax:+82-54-279-3399
    E-mail:
    skchung@postech.ac.kr

 

                 

학력

 

 

 

1

1972-Univ. of Illinois, Urbana-Champaign(박사-생유기화학,의약화학)

2

1968-연세대학교(학사-화학)

             

주요경력

 

 

 

1

1983/08-1987/02:SmithKline & French Lab., Senior Investigator

2

1977/08-1983/07:Texas A&M University(화학과), Assistant Professor

3

1975/09-1977/08:Yale University(화학과), Staff Scientist

4

1972/08-1975/08:Yale University(화학과), Postdoc Associate

5

1968/09-1972/07:University of Illinois(화학과), TA & RA

6

1966/09-1968/07:연세대학교(화학과), 조교

                

전문분야

 

 

 

1.

천연물화학 : 구조결정, 합성 및 생합성에 대한 연구

2.

의약화학 : 수용체와 효소의 구조 및 기작에 근거한 약물설계 및 합성, SNP와 약물설계

3.

합성 유기화학 : 합성에 유용한 새로운 반응의 개발 및 반응 메카니즘 연구

4.

생유기화학 : 효소 반응들에 대한 반응 메카니즘의 연구 및 모델 반응의 설계, Cellular Signal Transduction 기작연구

                

 

 

전문학술지논문

 

 

1

Y. T. Chang, J. Choi, S. Ding, E. E. Prischl, T. Baumruker, J. M. Lee, S. K. Chung, P. G. Schultz, "The Synthesis and Biological Characterization of Ceramide Library", J. amer. chem. Soc., Vol.124, pp.1856-1857 American Chemical Society (2002).

2

M. W. Y. Ho, X. Yang, M. A. Carew, T. Zhang, Y. U. Kwon, S. K. Chung, S. Adelt, G. Vogel, A M. Riley, B. V. L. Potter, S. B. Shears, "Regulation of Ins(3456)P4 Signaling by a Reversible Kinase/Phosphatase", Current Biology, Vol.12, pp.477-482 Elsevier Science (2002).

3

Y. T. Chang, G. Choi, Y. S. Bae, M. Burdett, H. S. Moon, J. W. Lee, N. S. Gray, P. G. Schultz, L. Meijer, S. K. chung, K. Y. Choi, P. G. Suh, S. H. Ryu, "Purine-based Inhibitors of Inositol-1,4,5-trisphosphate 3-kinase", ChemBiochem, Vol.3, pp.897-901 Wiley-VCH (2002).

4

Y. U. Kwon, C. Lee, S. K. Chung, "Facile Syntheses of All Possible Enantiomeric Pairs of Conduritol and Inositol Stereoisomers from myo-Inositol", J. Organic Chem., Vol.67, pp.3327-3338 American Chemical Society (2002).

5

S. K. Chung, Y. U. Kwon, J. H. Shin, y. T. chang, D. G. Lee, B. G. Shin, K. C. Kim, M. J. Kim, "Divergent syntheses of all Possible Optically Active Regioisomers of myo-Inositol Tris- and Tetrakisphosphate", J. Organic Chem., Vol.67, pp.5626-5637 American Chemical Society (2002).

6

Y. H. Ahn, S. K. Chung, "A Study of Benzene 1,2,4-trisphosphate Derivatives as Inositol 1,4,5-Trisphosphate 3-Kinase Inhibitors", Bull. Korean chem. Soc., Vol.23, pp.515-517 Korean Chemical Society (2002).

7

J. M. Lee, H. S. Lim, S. K. chung, "A Short and Efficient Stereoselective Synthesis of All Diastereomers of Sphingosine", Tetrahedron:Asymmetry, Vol.13, pp.343-347 Elesevier Science (2002).

8

Yong-Uk Kwon and Sung-Kee Chung, "Facile Synthetic Routes to All Possible Enantiomeric Pairs of Conduritol Stereoisomers via Efficient Enzymatic Resolution of Conduritol B and C Derivatives", Org. Lett., Vol.3(19), , pp.3013-3016 American Chemical Society (2001.09).

9

S. K. Chung and K. H. Park, "A Novel Approach to the Stereoselective Synthesis of b-D-Mannopyranosides", Tetrahedron Lett., Vol.42, pp.4005-4007 Pergamon (2001.06).

10

Y. T. Chang, G. R. Rosania, and S. K. Chung, "Inositol Phospholipid Pathway Inhibitors and Regulators", Expert Opin. Ther. Pat., Vol.11, pp.45-59 Ashley (2001.01).

11

T. W. Kwon, Y. M. Kim, S. J. Song, Y. U. Kwon, and S. K. Chung, "Synthesis of Thiophenyl Substituted Cyclohexa-2,4-dien-1-one and its Photocleavage Coupling Reactions with Amines", Bioorg. Med. Chem. Lett., Vol.10, pp.1551-1553 Elsevier Science (2000.07).

12

Y. M. Kim, S. J. Song, T. W. Kwon, and S. K. Chung, "Photolytic Cleavage and Condensation Reactions of Cyclohexa-2,4-dienones with Diamines", Molecules, Vol.5, pp.961-966 MOLECULAR DIVERSITY PRESERVATION INTERNA (2000).

13

B. C. Suh, M. J. Kim, G. Choi, K. Y. Choi, J. K. Han, S. K. Chung, and K. T. Kim, "Differential stereoselectivity of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate binding to the inositol 1,4,5-trisphosphate receptor and 3-kinase", Neurochem. Int, Vol.37, pp.47-52 Elsevier Science (2000).

14

S. K. Chung, K.-W. Lee, H. I. Kang, C. Yamashita, M. Kudo, and Y. Yoshida, "Design and Synthesis of Potential Inhibitors of the Ergosterol Biosynthesis as Antifungal Agents", Bioorg. Med. Chem., Vol.8, pp.2475-2486 Elsevier Science (2000).

15

S. K. Chung, Y. U. Kwon, Y. H. Ahn, T. H. Jeong and Y. T. Chang, "A Novel DAST-induced Debenzylative Cycloetherization in D-1,2-O- Isopropylidene-3,4,5-tri-O-benzyl-myo-inositol", Bull. Kor. Chem. Soc, Vol.21, pp.274-276 Kor. Chem. Soc (2000).

16

S. K. Chung, L. M. Zhao, and Y. Ryu, "Synthesis of DL-6-O-(2-Amonoethyl-1-phospho)-myo-inositol-1,3,4,5-tetrakisphosphate as a Precursor of Affinity Material for I(1,3,4,5)P4 Binding Proteins", Bull. Kor. Chem. Soc., Vol.20, pp.846 Korean chemical society (1999).

17

S. K. Chung, Y. U. Kwon, Y. T. Chang, K. H Sohn, J. H. Shin, K. H. Park, B. J. Hong, and I. H. Chung, "Synthesis of All Possible Regioisomers of scyllo-Inositol phosphate", Bioorg. Med. Chem., Vol.7, pp.2577 Elsevier Science (1999).

18

S. K. Chung and J. M. Lee, "Stereoselective Synthesis of beta-Amino Alcohols: Practical Preparation of All Four Diastereomers of N-PMB-protected Sphingosine from L- and D-serine", Tetrahedron: Asymmetry, Vol.10, pp.1441 Pergamon Press (1999).

19

T. Hanck, R. Stricker, U. M. Krishna, J. R. Falck, Y. T. Chang, S. K. Chung and G. Reiser, "Specific Association of p42IP4, a 42 kDa high-affinity Ins 1,3,4,5-P4/ PtdIns 3,4,5-P3 receptor protein, with PtdIns 3,4,5-P3-containing lipid vesicles", Eur. J. Biochem., Vol.261, pp.577 (1999).

20

S. K. Chung and Y. U. Kwon, "Practical Synthesis of All Inositol Stereoisomers from myo-Inositol", Bioorg. Med. Chem. Lett., Vol.9, pp.2135 Elsevier Science (1999).

21

Y. M. Kim, T. W. Kwon, D. H. R. Barton, and S. K. Chung, "Photocleavage Coupling Reactions between Cyclohexa-2,4-dienone Sulfone Derivatives and Amines Under Irradiation with Visible Light", Bioorg. Med. Chem. Lett., Vol.9, pp.1175 Elsevier Science (1999).

22

T. W. Kwon, S. K. Chung and M. B. Smith, "Mass Spectra of 2-Substituted Diethyl Malonate Derivatives", Molecules, Vol.4, pp.62-68 MOLECULAR DIVERSITY PRESERVATION INTERNA (1999).

23

X. Yang, M. Rudolf, M. A. Carew, M. Yoshida, V. Nerreter, A. M. Riley, S. K. Chung, K. S. Bruzik, B. V. L. Potter, C. Sc, "Ins(1,3,4)P3 acts in vivo as a specific Regulator of Cellular Signalling by Ins(3,4,5,6)P4", J. Biol. Chem., Vol.274, pp.18973 (1999).

24

Y. M. Kim, T. W. Kwon, S. K. Chung and M. B. Smith, "A Facile One-step Synthesis of Ethyl 2-(1,1-Dialkyl and Arylmethyl)malonates", Syn. Commun., Vol.29, pp.343-350 Marcel Dekker (1999).

25

S.K.Chung, B.G. Shin, Y.T.Chang, B.C.Suh, K.T.Kim, "Synthesis of D- and L-myo-inositol-1,2,4,5-tetrakisphosphate and Stereoselectivity of the I(1,4,5)P3 Receptor Binding", Bioorg.Med.Chem.Letters, Vol.8, pp.659 Elsevier Science (1998).

26

S.K.Chung, C.H.Ryoo, H.W.Yang, J.Y.Shim, M.K.Kang, K.W.Lee, H.I.Kang, "Synthesis and Bioactivities of Steroid Derivatives as Antifungal Agents", Tetrahedron, Vol.54, pp.15899 Elsevier Science (1998).

27

S.K.Chung, Y.T.Chang, E.J.Lee, B.G.Shin, Y.U.Kwon, K.C.Kim, D.H.Lee, M.J.Kim, "Syntheses of Two Enantiomeric Pairs of myo-Inositol 1,2,4,5,6- and 1,2,3,4,5-pentakisphosphate", Bioorg.Med.Chem.Letters, Vol.8, pp.1503 Elsevier Science (1998).

28

S.K.Chung, Y.T.Chang, "Syntheses of D-myo-Inositol 1,2,6-triphosphate and 2,6-bisphosphate", J.Carbohydrate Chem., Vol.17, pp.385 Marcel Dekker (1998).

29

S.K.Chung, Y.T.Chang, Y.U.Kwon, "Syntheses of All Regioisomers of myo-Inositol bisphosphate", J.Carbohydrate Chem., Vol.17, pp.369 Marcel Dekker (1998).

30

S.K.Chung, J.Y.Shim, M.K.Kang, K.W.Lee, H.I.Kang, "Studies of Steroids as Potential Antifungal Agents 2. Side Chain Modified Cholesterols", Kor.J.Med.Chem., Vol.8, pp.14 Korean Chemical Society (1998).

31

S.K.Chung, C.H.Ryoo, H.W.Yang, J.Y.Shim, H.I.Kang, "Studies of Steroids as Potential Antifungal Agents 1, Side Chain Modified Lanosterols", Kor.J.Med.Chem, Vol.8, pp.10 Korean Chemical Society (1998).

32

S.K.Chung, T.H.Jeong, D.H.Kang, "Novel Asymmetric Phenylselenium-induced Lactamizations of Olefinic Amides; Highly Stereoselective Routes to α- and β-Amino Acids.", J.C.S.Perkin Trans. I, , pp.969 (1998).

33

S.K.Chung, Y.T.Chang, E.J.Lee, Y.U.Kwon, "An Efficient Synthesis of D-myo-Inositol 1,3,4,5-tetrakisphosphate", Kor.J.Med.Chem., Vol.8, pp.18 Korean Chemical Society (1998).

34

K.S Kim, S.J.Cho, K.S.Oh, J.S.Son, J.Kim, J.Y.Lee, S.J.Lee, S.Lee, Y.T.Chang, S.K.Chung, T.K.Ha, B.S, Lee and I.Lee, "Theoretical Studies of Regioselectivity of myo-Inositol Derivatives:Importance of Solvent Dielectric Constants", J. Phys. Chem. A, Vol.101, pp.3776 Amer. Chem. Soc. (1997).

35

S. K. Chung, Y. U. Kwon, and Y. T. Chang, "Synthesis of D-Galactopyranosyl-1,2,6-trisphosphates as a Geometric Analogue of D-myo-Inositol 1,4,5-trisphosphate", Kor. J. Med. Chem., Vol.7, pp.63 Kor. Chem. Soc. (1997).

36

S. K. Chung and Y. T. Chang, "Syntheses of myo-Inositol-1,2,3,5- and-2,4,5,6-tetrakisphosphates. Unusual Inhibitors of myo-Inositol-1,4,5-trisphosphate 3-Kinase", Bioorg. Med. Chem. Lett., Vol.7, pp.2715 Pergamon Press (1997).

37

S. K. Chung and D. H. Kang, "Stereoselective Synthesis of β-Amino Alcohols: Diastereoselctive Reduction of Chiral α'-Amino Enones Derived from Amino Acids", Tetrahedron: Asymmetry, Vol.8, pp.3027 Pergamon Press (1997).

38

S. K. Chung and Y. T. Chang, "Solution Conformation and Kinetic Acidity of 1,2:4,5-Di-O-isopropylidene-myo-inositol", Kor. J. Med. Chem., Vol.7, pp.15 Kor. Chem. Soc. (1997).

39

S. K. Chung, Y. T. Chang, J. W. Lee and Y. K. Ji, "Selective Benzoylations of myo-Inositol Orthoformate and a Practical Synthesis of myo-Inositol 1,3,4,5-tetrakisphosphate", Kor. J. Med. Chem., Vol.7, pp.82 Kor. Chem. Soc. (1997).

40

J. S. Marchant, Y. T. Chang, S. K. Chung, R. F. Irvine and C. W. Taylor, "Rapid kinetic measurements of 45Ca2+ mobilization reveal that inositol 2,4,5-trisphosphate is a partial agonist at hepatic inositol trisphosphate receptors", Biochem. J., Vol.321, pp.573 Portland Press (1997).

41

D. H. R. Barton, S. K. Chung, Y. M. Kim and T. W. Kwon, "Photochemically Induced Symmetric Coupling Reactions Between Cyclohexa-2,4-dienones and a,w-Diamines. A New Approach to the Selective Labelling of Peptides and Proteins", Bioorg. Med. Chem. Letters, Vol.7, pp.733 Pergamon Press (1997).

42

S. K. Chung, Y. T. Chang and K. H. Sohn, "New Approaches to the Synthetic Problems of myo-Inositol Phosphates and their Biological Utilities", Medicinal Chemistry: Today and Tomorrow, , pp.63 Blackwell Science (1997).

43

Y. T. Chang, S. K. Chung, G. Choi and K. Y. Choi, "Molecular Probes for the Binding of myo-Inositol 1,4,5-Trisphosphate(IP3) 3-kinase and Comparison with IP3 Receptor", Kor. J. Med. Chem., Vol.7, pp.106 Kor.Chem. Soc. (1997).

44

Y. T. Chang, S. K. Chung, G. Choi and K. Y. Choi, "Molecular Interactions of all Possible Regioisomers of Synthetic myo-Inositol Phosphates with myo-Inositol 1,4,5-Trisphosphate 3-kinase", Bioorg. Med. Chem. Lett., Vol.7, pp.2709 Pergamon Press (1997).

45

P. S. Kwon, Y. M. Kim, C. J. Kang, T. W. Kwon, S. K. Chung and Y. T. Chang, "Microwave Enhanced Knoevenagel Condensation of Malonic Acid on Basic Alumina", Syn. Commun., Vol.27, pp.4091 Marcel Dekker (1997).

46

S. Y. Kim, P. S. Kwon, T. W. Kwon, S. K. Chung and Y. T. Chang, "Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes", Syn. Commun., Vol.27, pp.533 Marcel Dekker (1997).

47

P. S. Kwon, J. K. Kim, T. W. Kwon, Y. H. Kim, and S. K. Chung,, "Microwave Enhanced Acetylation and Nitration of Aromatic Compounds", Bull. Kor. Chem. Soc., Vol.18, pp.1118 Kor. Chem. Soc. (1997).

48

N. T. Burford, S. R. Nahorski, S. K. Chung, Y. T. Chang, and R. A. Wilcox, "Binding and Activity of the Nine Possible Regioisomers of myo-Inositol Tetrakisphosphate at the Inositol 1,4,5-Trisphosphate Receptor", Cell Calcium, Vol.21, pp.301 Churchil Livingstone (1997).

49

S. K. Chung, T. H. Jeong and D. H. Kang, "A Diastereoselctive Phenylselenium-induced Lactamization of Olefinic Amides. A. Possible Route to α- and β-Amino Acid Derivatives", Tetrahedron: Asymmetry, Vol.8, pp.5 Pergamon Press (1997).

50

S. K. Chung, J. W. Lee, N. Y. Shim and T. W. Kwon, "p-Quinone Methides as Geometric Analogues of Quinolone Carboxylate Antibacterials", Bioorg. Med. Chem. Lett., Vol.6, pp.1309 (1996).

51

S. J. Lee, S. J. Cho, K. S. Oh, C. Cui, Y. Ryu, Y. T. Chang, K. S. Kim and S. K. Chung, "ab initio Conformational Study of 1,2:4,5-Di-O-isopropylidene-myo-inositol", J. Phys. Chem., Vol.100, pp.10111 (1996).

52

S. K. Chung and Y. T. Chang, "Synthesis of myo-Inositol-1,2,3-trisphosphate by Selective Benzylation: the Iron binding Motif of Physic Acid (IP6)", ibid., Vol.6, pp.253 (1996).

53

S. K. Chung and S. H. Yu, "Synthesis of L-chiro-inositol 1,2,3-trisphosphate and L-chiro-inositol 1,2,3,5-tetrakisphosphate by Ferrier Reaction of Methyl α-D-Mannopyranoside", Bioorg. Med. Chem. Lett., Vol.6, pp.1461 (1996).

54

S. K. Chung and Y. T. Chang, "Synthesis of All possible Regioisomers of myo-Inositol Pentakisphosphate", Bioorg. Med. Chem. Lett., Vol.6, pp.2039 (1996).

55

I. D. Spiers, C. J. Barker, S. K. Chung, Y. T. Chang, S. Freeman, J. M. Gardiner, P. H. Hirst, P. A. Lambert, et. al., "Synthesis and Iron Binding Studies of myo-Inositol 1,2,3-tris-phosphate and DL-myo-Inositol 1,2-bisphosphate, and Iron Binding Studies of All Regioisomers of myo-Inositol tetrakisphosphates", Carbohydrate Res., Vol.282, pp.81-99 (1996).

56

D. H. R. Barton, S. K. Chung and T. W. Kwon, "Photochemical Cleavage of Cyclohexa-2.4-dienones under Irradiation with Visible Light", Tetrahedron Lett., Vol.37, pp.3631 (1996).

57

S. K. Chung and S. H. Yu, "Ferrier Reaction Applied to Methyl α-D-Mannopyranoside. Efficient Synthesis of L-chiro-inositol-1,2,3-trisphosphate and 1,2,3,5-tetrakisphosphate", Kor. J. Med. Chem., Vol.6, pp.35 (1996).

58

R. Stricker, Y. T. Chang, S K. Chung, and G. Reiser, "Determination of Specificity of a High-affinity Inositol 1,3,4,5-tetrakisphosphate Binding Site at a 42 KDa Receptor Protein P42IP4 : Comparison of Affinities of All Inositol P3, -P4, and P5 Regioisomers", Biochem. Biophys. Res. Commun, Vol.228, pp.596 (1996).

59

S. K. Chung, J. W. Lee, N. Y. Shim and T. W. Kwon, "Design and Synthetic Studies of Geometric Analogues of Quinolone Carboxylate Antibacterials. 3", Korean J. Med. Chem., Vol.6, pp.22 (1996).

60

S. K. Chung, Y. T. Chang, D. Whang and K. Kim, "Crystal Structures of DL-2,3-O-isopropylidene-1,4-O-dibenzoyl-myo-inositol and DL-5,6-O-isopropylidene-1,4-O-dibenzoyl-myo-inositol: A Conformational Analysis", Carbohydrate Res., Vol.295, pp.01월 06일 (1996).

61

S. K. Chung and D. H. Kang, "Asymmetric Synthesis of α-Aminophosphonates via Diastereoselective Addition of Phosphite to Chiral Imine Derivatives", Tetrahedron:Asymmetry, Vol.7, pp.21 (1996).

62

J. K. Kim, P. S. Kwon, T. W. Kwon, S. K. Chung and J. W. Lee, "Application of Microwave Irradiation Techniques for the Knoevenagel Condensation", Synth. Comm., Vol.26, pp.535 (1996).

63

S. K. Chung and Y. T. Chang, "A divergent Synthesis of All possible Regioisomers of myo-Inositol Monophosphate", Kor. J. Med. Chem., Vol.6, pp.162 (1996).

64

S. K. Chung, Y. T. Chang and K. H. Sohn, "A Practical, Divergent Synthesis of All Possible Regioisomers of myo-Inositol Triphosphates", J. C. S. Chem. Comm., , pp.163 (1996).

65

G. D. Han and S. K. Chung, "A New Method for Conversion of Nitriles to Primary Alcohols", Chinese Chemical Letters, Vol.7, pp.1079 Chinese Chem. Soc. (1996).

66

S. K. Chung, Y. T. Chang and Y. Ryu, "A Divergent Approach toward Synthesis of myo-Inositol Phosphates:Acyl Migrations and Regioselectivity", Pure & Appl. Chem., Vol.68, pp.931 (1996).

67

S. K. Chung and Y. T. Chang, "Synthesis of All Possible Isomers of myo-Inositol Tetrakisphosphate", J. C. S. Chem. Comm., , pp.11 (1995).

68

S. K. Chung, S. H. Ban, S. H. Kim, B. E. Kim, S. H. Woo, J. B. Summers and R. G. Conway, "Synthesis and Bioactivities of Heterocyclic Lipids as PAF Antagonists.2", Bioorg. Med. Chem. Letters, Vol.5, pp.1097 (1995).

69

S. K. Chung, S. H. Ban, S. H. Kim, B. E. Kim, S. H. Woo, J. B. Summers and R. G. Conway, "Synthesis and Bioactivities of Heterocyclic Lipids as PAF Antagonists.1", Bioorg. Med. Chem. Letters, Vol.5, pp.1091 (1995).

70

P. J. Cullen, S. K. Chung, Y. T. Chang, A. P. Dawson and R. F. Irvine, "Specificity of Purified Inositol(1,3,4,5) Tetrakisphosphate-binding Protein from Porcine Platelets", FEBS Letters, Vol.358, pp.240 (1995).

71

S. K. Chung and Y. T. Chang, "Base-catalyzed Acyl Migrations in myo-Inositol Dibenzonates", J. C. S. Chem. Comm., , pp.13 (1995).

72

S. K. Chung and S. H. Moon, "Synthetic Studies of D-Mannose phosphates and phosphonates and Their Biological Activities", Carbohydr. Res., Vol.260, pp.39 (1994).

73

S. K. Chung and S. H. Yu, "Synthesis of D-6-Deoxy-6,6-difluoro-myo-Inositol", Kor. J. Med. Chem., Vol.4, pp.80 (1994).

74

S. K. Chung and Y. Ryu, "Regioselective Functionalizations and Confornation Studies of Di-O-isopropylidene-myo-inositol Derivatives", Carbohydr. Res., Vol.258, pp.145 (1994).

75

Sung-Kee Chung and Sung-Hwan Moon, "Synthesis of (1-Deoxy-4,5-O-bisphosphoryl-β-D-mannopyranosyl) methane Phosphonate as Amalogue of L-myo-Inositol-1,4,5-trisphosphate", J. C. S. Chem. Comm., , pp.77 (1992).

76

N, A. I. Scott, R. Shankaranarayan and S. K. Chung, "Concerning the Intermediacy of Monocyclic β-Lactams in Penicillin Biosynthesis. Synthesis and Attempted Bioconversion of secoisopenicillin", Heterocycles, Vol.30, pp.909 (1990).

77

S. K. Chung, "Computer Graphics/Molecular Mechanics Studies on Non-Classical β-Lactam Structures", Bull. Kor. Chem. Soc., Vol.10, pp.216 (1989).

78

S. K. Chung, S. L. Heald and P. W. Jeffs, "Preparation and Characterization of Dechlorinated Ardacin Antibiotics", J. Org. Chem., Vol.52, pp.1606 (1987).

79

S. K. Chung, P. Taylor, Y. K. Oh, S. DeBrosse abd P. W. Jeffs, "Biosynthetic Studies of Aridicin Antibiotics I: Labelling Patterns and Overall Pathways", J. Antibiotics, Vol.39, pp.642 (1986).

80

S.U.Park, S.K.Chung, M. Newcomb, "Acceptor, Donor and Capto-dative Stabilization in the Transition States of 5-Hexenyl Radical Cyclizations", J. Am. Chem. Soc., Vol.108, pp.240 American Chemical Society (1986).

81

S. K. Chung, S. U. Park, "Mechanistic Probes of the Hydride Transfer Process in the NADH-dependent Alcohol Dehydrogenase Reactions", J. Org. Chem., Vol.47, pp.3197 (1982).

82

S. K. Chung, "Mechanism of the Cannizzaro Reactions: Possible Involvement of Radical Intermediates", J. C. S. Chem. Comm., , pp.480 (1982).

83

S. K. Chung, "Selective Reduction of Mono-, Di-substituted Olefins by Co(II) and NaBH4", J. Org. Chem., Vol.44, pp.1014 (1979).

84

S. K. Chung, "Reduction of Vinyl Bromides with LiAlH4: Evidence for a Radical Mechanism", J. Org. Chem., Vol.45, pp.1014 (1979).

85

A. I. Scott, J. Kang, D. Dalton and S.K. Chung, "The Mechanism of Action of Coenzyme B12: An Overall Carbanionic Mechanism for Carbon-skeleton Rearrangement in a Model Reaction", J. Am. Chem. Soc., Vol.100, pp.3603 (1978).

86

S.K. Chung, D.B. Copsey and A. I. Scoot, "Template-directed Organic Synthesis. A Model for Peptidyl Transfer Reaction of Protein Biosynthesis", Bioorganic Chem., Vol.7, pp.303 (1978).

87

A. I. Scott, U. Sequin, C. T. Bedford and S. K. Chung, "The Structure of the Antibiotic Hedamycin", Helv. Chim. Acta, Vol.60, pp.896 (1977).

88

A. I. Scott, C. J. Wiesner, S. K. Chung, "Acetyl Transfer Reaction in Catechol Acetate Malonate : A Model for the Biosynthesis of Polyketides and Fatty Acids", J. Am. Chem. Soc., Vol.97, pp.6277 (1975).


학술회의논문

 

 

1

S. K. Chung, "Studies on the Diastereoselective Synthesis of beta-Amino Alcohols and Amino Acids (Invited lecture)", the 119th Annual Meetings of Pharmaceutical Society of Japan, Tokushima, Japan (1999.03.29).

2

S.K.Chung, "Steroid Derivatives as Antifungal Agents", The 6th Japan-Korea Joint Symposium on Drug Design and Development, , pp.71-76 Tokyo, Japan (1998).

3

S. K. Chung, "Synthetic and Biological Studies of myo-Inositol Phosphates as Second Messengers (plenary lecture)", Symposium on Natural Product Chemistry, Salerno, Italy (1997).

4

S. K. Chung, "Synthetic and Biological Aspects of myo-Inositol Phosphates as Second Messengers (invited lecture)", 7th Asian Chemical Congress, , pp.383 Hiroshima,Japan (1997).

5

S. K. Chung, "Recent Studies on Asymmetric Synthesis of α-Aminophosphonates", The 8th Japan-Korea Seminar on Organic Chemistry, Tokyo (1996).

6

S. K. Chung, "Recent Studies of Asymmetric Synthesis of Amino Acids and Aminophosphonates", The 5th Korea-Japan Joint Symposium on Medicinal Chemistry, Kyong-Ju (1996).

7

S. K. Chung, "Design, Synthesis and Bioactivities of Heterocyclic Lipids as PAF Antagonists", The first Korea-Italy Joint Symposium on Medicinal Chemistry, Seoul (1996).


학회발표

 

 

1

Y. U. Kwon, C. Lee S. K. chung, "Facile Syntheses of All Possible Diastereomers of Conduritol and Various Derivatives of Inositol Stereoisomers in High Enantiopurity fron myo-Inositol", 223rd ACS national Meeting in Orlando, Florida, USA, (20020409-20020411).

2

H. S. Lim, J. M. Lee, S. K. chung, "Synthesis of All Four Diastereomers of S1P and Their Derivatives and Their Interaction with EDG Receptors", 223rd ACS National Meeting in Orland, Florida, USA, (20020407-20020411).

3

권용억, 이창국, 정성기, "Facile Synthetic Routes to All Possible Enantiomeric Pairs of Conduritol and Inositol Stereoisomers", 88회 대한화학회 추계총회, 부산, 부경대 (20011019-20011020).

4

안영훈, 정성기, "Design and Synthetic Studies of Inositol 1,4,5-Trisphosphate 3-Kinase Inhibitors", The 86th Annual Meeting of the Korean Chemical Society, 대한화학회/경상대 (2000.10.21).

5

S. K. Chung, Y. U. Kwon, C. G. Lee, B. G. Shin and Y. H. Ahn, "Divergent Synthesis of All Possible Optically Active Regioisomers of myo-Inositol Tetrakisphosphate (myo-IP4)", the 220th American Chemical Society National Meeting, American Chemical Society/Washington D.C. (2000.08.20).

6

정성기, 이재목, 이창국, "Diastereoselective Synthesis of b-Amino-a-Hydroxy Carboxylates", The 85th Annual Meeting of the Korean Chemical Society, 대한화학회/국민대 (2000.04.22).

7

K. H. Park and S. K. Chung, "Studies on Stereoselective Synthesis of beta-Mannoglycosides", the 84th Annuanl Meeting of the Korean Chemical Society, Sunchun National University, Sunchun (1999.10.22).

8

J. M. Lee and S. K. Chung, "Diastereoselective Synthesis of D-Erythro and L-Threo-Sphingosine from L-Serine", the 84th Annuanl Meeting of the Korean Chemical Society, Sunchun National University, Sunchun (1999.10.22).

9

L.M.Zhao, Y.Ryu, S.K.Chung, "Synthesis of DL-6-O-(2 Aminoethyl-1-phospho)-myo-Inositol-1,3,4,5-tetrakisphosphate", National Meetings of Korean Chemical Society, SunMoon University (1998).

10

Y.U.Kwon, J.H.Shin, S.K.Chung, "Synthesis of All Possible Regioisomers of scyllo-Inositol Tris- and Tetrakisphosphates", National Meetings of Korean Chemical Society, Ewha Woman's University (1998).

11

J.H.Shin, S.K.Chung, M.J.Kim, "Synthesis of All Possible Regioisomers of Chiral myo-Inositol Trisphosphates", National Meetings of Korean Chemical Society, Ewha Woman's University (1998).

12

S.K.Chung, "Steroid Derivatives as Antifungal Agents", Japan-Korea Joint Symposium on Drug Design and Development, Tokyo, Japan (1998).

13

D.H.Kang, S.K.Chung, "Recent Studies on Optically Active a-Aminophosphonic Acids via Tricomponent Condensation Reaction", Korea-Japan Young Chemists Seminar, Pusan National University (1998).

14

J.M.Lee, S.K.Chung, "Diastereoselective Synthesis All four Stereoisomers of N-Protected Sphingosine from L- and D-serine", National Meetings of Korean Chemical Society, SunMoon University (1998).

15

S. K. Chung and K. H. Paik, "Synthesis of α,α7-Disubstituted α-amino Acids via Asymmetric Lactamization of Olefini Amides (poster)", National Meetings of Korean Chemical Society, (1997).

16

S. K. Chung, Y. M. Kim, and T. W. Kwon, "Synthesis of New Cyclohexa-2,4-dien-1-one Derivatives and Their Photolysis Reaction (poster)", National Meetings of Korean Chemical Society, (1997).

17

S. K. Chung and Y. U. Kwon, "Synthesis of Inositol Stereoisomers via Conduritols (poster)", National Meetings of Korean Chemical Society, (1997).

18

S. K. Chung and D. H. Kang, "Stereoselective Synthesis of β-Amino Alcohols: Diastereoselective Reduction of Chiral α'-Amino Enones Derived from Amino Acids (poster)", National Meetings of Korean Chemical Society, (1997).

19

S. K. Chung, "Recent Studies on the Intracellular Signal Transduction (invited lecture)", Annual meeting of Korean Chemical Society, Taegu-KyungBuk Chapter, POSTECH (1997).

20

S. K. Chung, "Recent Studies on the Diastereoselective Synthesis of a-Aminophosphonates and a/b-Amino Carboxylates (invited seminar)", , University of Rome ''La Sapienza" Italy (1997).

21

S. K. Chung, "Recent Excursions in the Synthetic and Medicinal Chemistry Areas (invited seminar)", , Cheil Chedang R/D Center (1997).

22

S. K. Chung and Y. T. Chang, "Binding Studies of IP4 Receptor from Pig Cerebellum with IPns (poster)", AFMC International Medicinal Chemistry Symposium, Seoul (1997).

23

S. K. Chung, "A Diastereoselective Phenylselenium-induced Lactamization of Olefinic Amides. Possible Routes to α- and β-Amino Acid Derivatives (invited lecture)", National Meetings of Korean Chemical Society, (1997).

24

S. K. Chung and M. K. Kang, "Synthetic Studies of C24-Aminosteroidal Compounds", National Meetings of Korean Chemical Society, Chungnam University (1996).

25

S. K. Chung and Y. T. Chang, "Synthesis of All Possible Regioisomers of myo-Inositol Pentakisphosphates", National Meetings of Korean Chemical Society, Yonsei University (1996).

26

S. K. Chung, Y. T. Chang and Y. U. Kwon, "Synthesis of All Possible Regioisomers of myo-Inositol Bisphosphates", National Meetings of Korean Chemical Society, Yonsei University (1996).

27

S. K. Chung, "Recent Synthetic and Biological Studies of myo-Inositol Phosphonates", The first Swiss-Korea Symposium on Pharmaceutical and Food Sciences, Zurich (1996).

28

S. K. Chung, "Recent Synthetic and Biological Studies of myo-Inositol Phosphates", Invited seminar, Department of Chemistry, Tohoku Univ. (1996).

29

S. K. Chung, "Recent Studies on Asymmetric Synthesis of Amino Acids and Aminophosphonates", Invited seminar, Pharmaceutical Institute, Tohoku Univ. (1996).

30

Y. M. Kim, T. W. Kwon and S. K. Chung, "Photochemical Coupling Reactions between Cyclohexa-2,4-dien-1-ones and Diamines", National Meetings of Korean Chemical Society, Chungnam University (1996).

31

D. H. R. Barton, S. K. Chung and T. W. Kwon, "Photochemical Cleavage of Cyclohexa-2,4-dienones: A New Procedure for the Labeling of Peptides and Amino Acids", National Meetings of Korean Chemical Society, Yonsei University (1996).

32

S. K. Chung and Y. T. Chang, "Inhibition of I(1,4,5)P3 kinase by Various IPn and Efficient Syntheses of myo-Inositol-1,3,4,5-and 2,4,5,6-tetrakisphosphates", National Meetings of Korean Chemical Society, Chungnam University (1996).

33

S. K. Chung, "Design, Synthesis and Bioactivities of Heterocyclic Lipids as PAF Antagonists - Potential Therapeutic Agents for Endotoxic Shock Syndrome", Invited seminar, SNU College of Pharmacy (1996).

34

S. K. Chung and T. H. Jeong, "A Novel Phenylselenium induced Lactamization of Olefinic Amides. A Highly Diastereoselective Route to α or β-Amino Acids", National Neetings of Korean Chemical Society, Yonsei University (1996).


 

◆ 연구실적

 

 

 

1

"생활성 분자의 선택적 인지및 합성연구", 한국학술진흥재단, 20020601-20030531

2

"생활성 분자의 선택적 인지및 합성연구", 한국학술진흥재단, 20010601-20020531

3

"생활성 분자의 산택적 인지 및 합성 연구", 포항공과대학교, 20001101-20011031

4

"생리분자화학 연구(책임자:문병조)", 기타, 19990301-20000229

5

"'99년도 생리분자과학연구센터 이월금", 기타, 19990301-20000229

6

"생체유용성 화합물의 입체선택적 합성", 기타, 19981201-19991130

7

"탄수화물과 아미노산을 이용한 생리활성물질의 합성연구 (이탈리아)", 기타, 19980401-20000331

8

"1998년 과학재단 지원금", 기타, 19980301-19990228

9

"1998년 전년도 이월금 예산", 기타, 19980301-19990228

10

"아미노산 유도체의 새로운 비대칭 합성법과 응용", 기타, 19980301-20000228

11

"생체유용성 화합물의 입체 선택적 합성 (IV)", 기타, 19970701-19980630

12

"1997년 전년도 이월금 예산", 기타, 19970301-19980228

13

"1997년 과학재단 지원금", 기타, 19970301-19980228

14

"myo - Inositol(1,4,5)P3-3-kINASE의 억제제 개발연구", 기타, 19961220-19981130

15

"생체유용성 화합물의 입체 선택적 합성Ⅱ", 기타, 19960701-19970630

16

"항진균 효과를 가지는 스테로이드에 관한 연구", 포항공과대학교, 19960701-19970630

17

"항진균 효과를 가진 STEROID에 관한연구", 포항공과대학교, 19960501-19970430

18

"1996년 과학재단 지원금", 기타, 19960301-19970228

19

"생체유용성 화합물의 입체선택적 합성(II)", 기타, 19950611-19960610

20

"항진균 효과를 가진 steroid에 관한 연구", ㈜태평양, 19950522-19960516

21

"항진군 효과를 가지는 스테로이드에 관한 연구 (기초 기술개발연구)", 포항공과대학교, 19950501-19960430

22

"전자충돌 여기 XUV 레이져 연구", 포항공과대학교, 19950401-19970228

23

"1995년 과학재단 지원금", 기타, 19950301-19960229

24

"생체유용성 화합물의 입체선택적 합성", 기타, 19940501-19950430

25

"1994년 과학재단 지원금", 기타, 19940301-19950228

                 

◆ 저서

 

 

 

1

정성기, 장영태, "인산이노시톨: 화학 및 생리학적 고찰", 민음사, 353p, 대우학술총서-자연과학122 (1998.06.05).

                  

◆ 지적재산권

 

 

 

1

정성기,이재목, "스핑고신 및 스핑가닌의 유도체의 제조방법", 한국, 특허, 등록번호 0349187 (2002.08.05).

2

정성기, 임현석, "신규한 스핑고신-1-포스페이트의 유도체 및 이의 제조방법", 한국, 특허, 출원번호 2002-0042857(2002.07.22).

3

정성기,이기화, "테트라하이드로푸란 유도체, 이의 제조방법 및 이를 포함하는 항진균제", 한국, 특허, 등록번호 0326276 (2002.02.15).

4

정성기, 이재목, 이창국, "베타-아미노-알파-히드록시 카르본산 및 그 유도체의 제조방법", 한국, 특허, 출원번호 2001-0082479(2001.12.21).

5

정성기,박규환,임현석, "β-D-만노피라노시드의 입체선택적 제조방법", 한국, 특허, 출원번호 2000-086281(2000.12.29).

6

정성기,양홍운,심증엽,강명구, "항진균 활성을 갖는 24-헤테로 원자치환된 스테로이드 화합물, 이의 제조방법및 이를 포함하는 항진균제", 한국, 특허, 등록번호 0203364 (1999.03.23).

7

정성기,이재목, "스핑고신 전구체 화합물, 그 제조방법 및 이를 이용한 스핑고신 유도체의 제조방법", 한국, 특허, 출원번호 1999-000102(1999.01.06).

8

정성기,장영태, "이노시톨 유도체와 그의 제조방법", 한국, 특허, 등록번호 149217 (1998.06.03).

9

정성기,강동호,정태흠, "광활성α-아미노산의 제조방법", 한국, 특허, 등록번호 140323 (1998.03.11).